Axoltis Pharma announces Phase 2 results for NX210c in ALS
Topline data shows reduced functional decline and target engagement, supporting continued clinical development.
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Biopharmaceutical company developing neurological disease treatments
axoltis.comLast updated
In short: Axoltis shared Phase 2 results for NX210c in ALS, which showed reduced functional decline despite missing the trial's primary endpoint.
Topline data shows reduced functional decline and target engagement, supporting continued clinical development.
The SEALS trial showed NX210c has a good safety profile and suggests efficacy signals in ALS patients at week 6.
The study, partnered with InSilicoTrials, shows encouraging results for relapsing-remitting multiple sclerosis. It leverages modeling tools for R&D in neurodegenerative diseases.
The second review of the SEALS Phase 2 ALS trial shows satisfactory safety and tolerability in the first 50 patients. Topline results expected Q2 2026.
The ALS development space has been notoriously difficult for companies to navigate, with only three disease-modifying therapies currently FDA approved.
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