Genmab and AbbVie clarify trial missed OS endpoint
The Phase 3 EPCORE DLBCL-1 study evaluated epcoritamab in relapsed/refractory DLBCL; overall survival, the US primary endpoint, was not met.
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Therapeutic antibody developer
genmab.comLast updated
In short: Genmab achieved significant growth in 2026, punctuated by a $1.8 billion acquisition of ProfoundBio and key EU approvals for Tepkinly.
The Phase 3 EPCORE DLBCL-1 study evaluated epcoritamab in relapsed/refractory DLBCL; overall survival, the US primary endpoint, was not met.
Sales were USD 2,435 million in the U.S. and USD 1,772 million in the rest of the world. Genmab receives royalties from Johnson & Johnson.
The bispecific antibody plus lenalidomide and rituximab offers a chemotherapy-free option, reducing risk of progression by 79% in the Phase 3 trial.
The combination showed statistically significant improvement in progression-free survival in relapsed/refractory DLBCL patients.
The Danish biotech company Genmab A/S has entered into an agreement to acquire the Dutch Merus NV. This is reported in the Genmab press release...
Genmab A/S (Nasdaq: GMAB) announced today updated data from cohort B2 of the Phase 1/2 RAINFOL-01 trial evaluating rinatabart sesutecan (Rina-S, an investigational folate receptor...
A drug co-developed by Genmab and AbbVie to treat a certain type of lymphoma failed to meet its primary endpoint in a Phase 3 trial...
Wednesday was another day of price hits for Danish stocks, which have only become less valuable since the week started. Danish stocks fell by 2.0 percent...
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