Fractyl reports durable weight maintenance after GLP-1 discontinuation
Data show optimized patients maintained 84% of prior GLP-1-induced weight loss vs 46% for sham, with no serious device-related events; REVEAL-1 corroborates results.
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Developer of metabolic therapies for obesity and type 2 diabetes
fractyl.comLast updated
In short: Fractyl Health achieved positive clinical data for its Revita procedure and initiated its first gene therapy trial for type 2 diabetes.
Data show optimized patients maintained 84% of prior GLP-1-induced weight loss vs 46% for sham, with no serious device-related events; REVEAL-1 corroborates results.
One-year REMAIN-1 data show durable weight maintenance after Revita, with pivotal readout expected early Q4 2026 and cash runway into early 2027.
Revita maintained 84% of weight loss vs 46% with sham at one year in optimized cohort.
Patients retained ~78% of GLP-1-induced weight loss after a single procedure; 33% continued losing weight.
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