Fractyl reports positive randomized data for weight maintenance after GLP-1 discontinuation
Revita maintained 84% of weight loss vs 46% with sham at one year in optimized cohort.
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Developer of metabolic therapies for obesity and type 2 diabetes
fractyl.comLast updated
In short: Fractyl Health advanced its metabolic pipeline with positive Revita weight maintenance data and the launch of a first-in-human gene trial.
Revita maintained 84% of weight loss vs 46% with sham at one year in optimized cohort.
Patients retained ~78% of GLP-1-induced weight loss after a single procedure; 33% continued losing weight.
The Netherlands authorized a Phase 1/2 study of RJVA-001, the first AAV gene therapy for type 2 diabetes, with dosing and preliminary data expected in H2 2026.
Results show reduced weight regain after GLP-1 discontinuation using Revita®. Dr. Sullivan presents six-month data at DDW2026 on May 4th.
Up to 84% of GLP-1 induced weight loss retained with Revita® versus 46% with shamat one year in patients receiving complete duodenal...
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